peptidyl transferase造句

• Peptidyl transferase is a ribozyme that facilitates formation of peptide bonds during translation.
• The "'Peptidyl transferase "'is an translation process of protein biosynthesis.
• In this case, an amino acid chain is the functional group transferred by a peptidyl transferase.
• Strobel's lab focuses on the biophysics and biochemistry of catalytic RNAs including riboswitches and the peptidyl transferase center.
• Streptogramin A first binds to the peptidyl transferase domain of the 50s ribosomal subunit, preventing the early events of elongation.
• The ribosomal peptidyl transferase activity resides in domain V of this rRNA, and this domain is the most common binding site for antibiotics that inhibit translation.
• Several proteins, including L32 / 33, L36, L21, L23, L28 / 29 and L13 were implicated as being at or near the peptidyl transferase center.
• In a 1964 publication, Warner and Rich showed that ribosomes active in protein synthesis contained tRNA molecules bound at the A and P sites, and discussed the notion that these molecules aided in the peptidyl transferase reaction.
• The N-terminal effector domain of HflX binds to the peptidyl transferase center in a strikingly similar manner as that of the class I release factors and induces dramatic conformational changes in central intersubunit bridges, thus promoting subunit dissociation.
• However, it is notable that, in ribosomal RNA, many of the post-transcriptional modifications occur in highly functional regions, such as the peptidyl transferase center and the subunit interface, implying that they are important for normal function.
• Steitz also won the Gairdner International Award in 2007 " for his studies on the structure and function of the ribosome which showed that the peptidyl transferase was an RNA catalyzed reaction, and for revealing the mechanism of inhibition of this function by antibiotics ".
• It does so by preventing the formation of the " initiation complex ", composed of the 30S and 50S subunits of the ribosome, 23S portion of the 50S subunit ( the center of peptidyl transferase activity ), close to the binding sites of chloramphenicol, lincomycin, and other antibiotics.
• The process of translation termination is universal and is mediated by protein release factors ( RFs ) and GTP . A class 1 RF recognizes the stop codon and promotes the hydrolysis of the ester bond linking the polypeptide chain with the peptidyl site tRNA, a reaction catalyzed at the peptidyl transferase center of the ribosome.